Supported formats in XMedia RecodeĪs we mentioned before, one of the main advantages of this software solution is the enormous compatibility it offers us. In it we find the usual timelines, or elements that we can include independently. What’s more, for these the XMedia Recode program offers a simple editor with preview from which we can further customize the videos we will get. This is composed of the title, duration, chapters if any, video format, audio tracks, etc. The files are then loaded into the main interface of the application with their own information visible. We find two depending on the video, Open Disk for DVD or Blu-Ray, as well as Open file for saved video files. Once we know all this, say that to start working with XMedia Recode, either we drag the contents to be treated, or we click on the corresponding button. How to use XMedia Recode to convert all kinds of videos At the same time, it is worth knowing that from here we also have the possibility of working with several files at the same time, which allows us to save a lot of time. To start working, all we have to do is click on the button called Encode that we see in the main interface. Moreover, at the same time XMedia Recode allows us to configure certain parameters so that in this way we can adapt these jobs even more. How could it be otherwise, once these have been loaded, we can select an output format and start the conversion work. In addition, and in order to make things easier, we can drag these contents directly to the main window of the program. In the beginning and in a basic way, for all this that we tell you we only have to select the disk or files to start with the conversion. In fact, from this program we can use almost all current video files, something that its developers are updating. Furthermore, if something characterizes this solution, it is the enormous compatibility with multiple digital formats that it presents. Thus, among other things, it allows us to convert a DVD, a Blu-Ray, or various files to other formats in a simple way. To give us a rough idea of what we are talking about now, this is actually a powerful video converter for PC. How will XMedia Recode help us on the PC? So, here we will talk about XMedia Recode, a software solution that has been around for a good number of years, a time in which it has not stopped improving. Precisely in order to adapt all this to the needs of each case or type of use, this is what these programs are for. It is not the same to watch a video on a mobile screen, than on a 4K television, for example. The same happens when we have to reproduce them on other devices. We tell you this because these files today we share with everyone through the Internet, which may require some conversion.
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For just a few dollars, pounds or Euros per month, Hayu is a specialist streaming service for reality TV addicts - and you can try it out for FREE with its 7-day trial. The episode will then drop on Friday, March 19 on Hayu for KUWTK fans around the globe. Keeping up with the Kardashians season 20 kicks off March, 18 at 8pm ET/PT and 7pm CT on E! When is Keeping up with the Kardashians season 20 on? Meanwhile, old flames might just be reigniting between Khloe and Tristan Thompson, and Kourtney and her baby daddy, Scott Disick.ĭon't miss a moment of the final season - here's how to watch Keeping up with the Kardashians season 20 where you are. If not the most iconic reality TV show, Keeping up with the Kardashians is certainly the longest-running, bringing together Kim, Kourtney and Khloe, alongside their half sisters Kendall and Kylie, and parents Kris and Caitlyn, as well as brother Rob and casting insight into their personal and professional lives.ĭubbed 'famous for being famous', Keeping up with the Kardashians is nothing if not a guilty pleasure for many, perhaps earning its popularity for its scandalous, presumably fabricated scenes with brawling sisters and messy break-ups.Īs the final ever season of the reality TV show dawns, we can expect to see what is likely to come next for the family as Kim sets her sights on a career in law, as well as the demise of her marriage to Kanye West. Get your final Kardashian fix and find out where to watch Keeping up with the Kardashians season 20 around the world right here. By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.Īfter almost 14 years of witnessing the milestones, cat fights and fallouts of the overly privileged Kardashian-Jenner clan, what feels like one of the ultimate reality TV shows is finally thankfully coming to an end with its twentieth season. Start in Safe Mode - This will run Firefox in Safe Mode without making any changes. When you restart in Safe Mode, you will see a Firefox Safe Mode window with two buttons: If you choose any of the troubleshooting options, the changes are only applied if you choose Make Changes and Restart.
ALYMSYS and RELUEKO launched in Q4 2022 and FYLNETRA launched in May. Third, in biosimilars, our first three oncology products are seeing strong uptake, particularly ALYMSYS, which is running ahead of our expectations. As we ramp up production at our new facilities and launch new products, we expect the next inflection of injectables revenue in 2024 building to over $300 million by 2025. With our recently added sites, we now have 4 injectable facilities to produce at scale across multiple formulations. Currently, we have about 30 injectables with over 30 new launches planned by 2025. Our strategy centers on being a key supplier of an expanding portfolio and offering a resilient supply chain in a market plagued by product shortages. Second, in injectables, our goal is to be a top 5 U.S. As shown on the catalyst slide, we expect to advance over a dozen high-value complex generics to the finish line by 2024. As we have discussed, complex generics tend to have less competitors and drive more durable growth, revenues and profit. So, first, in retail generics, we are expanding our portfolio of approximately 230 products to move up the value chain of complexity. And we expect that mix shift will continue. Approximately 55% of a generics revenue is expected to come from complex products in 2023 compared to 35% in 2019. We expect Generics revenue growth will accelerate over the next several years, driven by complex products. In the Generics segment, we have retail generics, injectables, biosimilars and international business. Let me now walk through how we are executing our strategy across the business. Based on the strength of our diversified portfolio, robust capabilities and opportunities ahead, Amneal is well positioned to drive sustainable long-term growth, accelerate profitability and continue deleveraging. Further, we have reduced net leverage from 7.4x in 2019 to 4.9x currently, well on our way to below 4x by the year 2025. We have delivered strong financial performance each year since 2019 as revenues have grown 10% and adjusted EBITDA has grown 12% on a CAGR basis. Today, Amneal has a diversified portfolio of approximately 270 marketed products, an industry-leading R&D engine, excellent commercial capabilities, a foothold in key global markets and significant growth catalysts ahead. Since then, we have methodically executed our long-term strategy to expand into high-growth and high-impact areas. At that time, we stated our goal was to return Amneal to growth and build a world-class diversified pharmaceutical company, driven by our purpose to provide access to high-quality and affordable essential medicines. On a personal note, this earnings call marks 4 years since Chintu and I returned to Amneal as Co-CEOs. As a result of our solid momentum in the first half, we are pleased to be raising our full year 2023 guidance. Q2 was another strong quarter with $599 million of revenue, growing 7%, adjusted EBITDA of $146 million, growing 9% and net leverage at 4.9x. Thank you, Tony, and good morning, everyone. On the call today are Chirag and Chintu Patel, Co-Founders and Co-CEOs Tasos Konidaris, CFO our Commercial leaders, Andy Boyer for Generics Joe Renda for Specialty Harsher Singh for Biosciences and Jason Daly, Chief Legal Officer. Information on our use of these measures in reconciliation to U.S. Please see the section entitled Cautionary Statements on Forward-Looking Statements in the earnings presentation and our SEC filings for a discussion of factors that may impact our future performance. Certain statements made on this call regarding matters that are not historical facts, including, but not limited to, management’s outlook or predictions are forward-looking statements that are based solely on information that is now available to us. Our Q2 earnings press release and presentation are available at. Good morning, and thank you for joining Amneal Pharmaceuticals second quarter 2023 earnings call. I will now hand over to your host, Anthony DiMeo, Head of Investor Relations. My name is Bruno, and I’ll be operating your call today. Hello, everyone and welcome to the Amneal Pharmaceuticals Second Quarter 2023 Earnings Conference Call. Tasos Konidaris - Chief Financial Officer ( NYSE: AMRX) Q2 2023 Earnings Conference Call Aug8:30 AM ETĬhirag Patel - Co-Founder and Co-Chief Executive OfficerĬhintu Patel - Co-Founder and Co- Co-Chief Executive Officer Spirit is not only the most useful trait it is also the most difficult to obtain.Īs with all other weapons and abilities, the traits of the other classes can also be obtained by playing. This means being able to use weapon mods more often, which is the key to fighting. Spirit, the former sect follower trait, increases the rate at which modifier energy is generated.If you like to get your hands dirty, it is not a bad idea, although it is generally preferable to fight from a distance. Warrior, the scrapper trait, increases the damage of melee attacks.Stealth has hardly any place in Remnant, so it's in all likelihood the least useful trait. Shadow Walker, the hunter trait, reduces the perception of enemies.In addition to stamina, each class begins with a trait that the others do not have: The first thing is that the class choice in Remnant: From the Ashes is not as important as in other similar games, at least not initially.Īs there are a large number of traits, some waiting to be collected in specific places and others depending on our luck "farming".Īnd therein lies the key that determines which is the best of Remnant: From the Ashes classes for you. There are three starting classes in Remnant: From the Ashes: If you haven't done it yet, we invite you to read our Remnant: From the Ashes review.Īnd since with their arrival on PlayStation Plus many players are going to enter this post-apocalyptic universe for the first time, we have decided to prepare a guide to help you with one of the first decisions you must make: What is the Best Class of Remnant From the Ashes? This title developed by Gunfire Games (currently responsible for the Darksiders saga) was released in 2019 and became an unexpected success thanks to its mix of third-person action, multiplayer elements, and soulslike style. Starting the 2nd of March 2021, the new PS Plus games are available, including Remnant: From the Ashes. If you are just starting to play Remnant: From the Ashes, we help you choose your class (or archetype): hunter, ex-cult follower, or junk dealer? Only one can be considered "the best" among the Ashes Classes. Small doses of heavy water (a few grams in humans, containing an amount of deuterium comparable to that normally present in the body) are routinely used as harmless metabolic tracers in humans and animals. Consumption of heavy water would not pose a health threat to humans unless very large quantities (in excess of 10 liters) were consumed over many days. Prokaryotic organisms, however, can survive and grow in pure heavy water (though they grow more slowly). Heavy water is slightly toxic in eukaryotic animals, with 25% substitution of the body water causing cell division problems and sterility, and 50% substitution causing death by cytotoxic syndrome (bone marrow failure and gastrointestinal lining failure). Bonds involving deuterium and tritium are somewhat stronger than the corresponding bonds in light hydrogen, and these differences are enough to make significant changes in biological reactions (see heavy water).ĭeuterium can replace the normal hydrogen in water molecules to form heavy water (D 2O), which is about 10.6% more dense than normal water (enough that ice made from it sinks in ordinary water). ĭeuterium behaves chemically similarly to ordinary hydrogen, but there are differences in bond energy and length for compounds of heavy hydrogen isotopes which are larger than the isotopic differences in any other element. The physical properties of deuterium compounds can be different from the hydrogen analogs for example, D 2O is more viscous than H 2O. India is now probably the world's largest concentrator of heavy water, also used in nuclear power reactors. Canada uses heavy water as a neutron moderator for the operation of the CANDU reactor design. The world's leading "producer" of deuterium (technically, merely enricher or concentrator of deuterium) was Canada, until 1997 when the last plant was shut down (see more in the heavy water article). Thus, the existence of deuterium is one of the arguments in favor of the Big Bang theory over the steady state theory of the universe. This abundance seems to be a very similar fraction of hydrogen, wherever hydrogen is found. Stellar fusion destroys deuterium, and there are no known natural processes (for example, see the rare cluster decay), other than the Big Bang nucleosynthesis, which might have produced deuterium at anything close to the observed natural abundance of deuterium. The existence of deuterium on Earth, elsewhere in the solar system (as confirmed by planetary probes), and in the spectra of stars, is an important datum in cosmology. Natural abundanceĭeuterium occurs in trace amounts naturally as deuterium gas, written ²H 2 or D 2, but most natural occurrence in the universe is bonded with a typical ¹H atom, a gas called hydrogen deuteride (HD or ¹H²H). The isotope weight ratios within other chemical elements are largely insignificant in this regard, explaining the lack of unique isotope symbols elsewhere. The reason deuterium has a distinct chemical symbol may be its large mass difference with protium (¹H) deuterium has a mass of 2.014 u, compared to the mean hydrogen atomic weight of 1.007947 u, and protium's mass of 1.007825 u. IUPAC allows both D and ²H, although ²H is preferred. Since it is an isotope of hydrogen with mass number 2, it is also represented by ²H. 6.3 "Heavy water" experiments in World War IIĭifferences between deuterium and common hydrogen (protium) Chemical symbolĭeuterium is frequently represented by the chemical symbol D.6.2 Deuterium predicted and finally detected.4.2 Approximated wavefunction of the deuteron.1 Differences between deuterium and common hydrogen (protium).The isotope name is formed from the Greek deuteros meaning "second", to denote the two particles comprising the nucleus. The nucleus of deuterium, called a deuteron, contains one proton and one neutron, whereas the far more common hydrogen nucleus contains no neutrons. However, it continues to persist in the outer solar atmosphere at roughly the same concentration as in Jupiter. There is little deuterium in the interior of the Sun, since thermonuclear reactions destroy it. Deuterium abundance on Jupiter is about 6 atoms in 10,000 (0.06% atom basis) these ratios presumably reflect the early solar nebula ratios, and those after the Big Bang. Deuterium thus accounts for approximately 0.015% (on a weight basis, 0.030%) of all naturally occurring hydrogen in the oceans on Earth (see VSMOW the abundance changes slightly from one kind of natural water to another). Deuterium, also called heavy hydrogen, is a stable isotope of hydrogen with a natural abundance in the oceans of Earth of approximately one atom in 6500 of hydrogen (~154 PPM). Laptop performance also depends heavily on configuration and cooling, so system benchmarks will always be king. What we have instead is a 5800U and 5700U that look like they only have 0.1GHz between them, but in fact have an architectural gap worth maybe 5x that.ĪMD aren’t alone in this kind of behaviour, teams Green and Blue could be accused of confusing naming too. It could have meant that the 5000 series would be Zen 3 only. On April 20, 2022, AMD also released the Ryzen 7 5800X3D desktop processor, which increases the single threading performance by another 15 in gaming by using. AMD has officially debuted its new Ryzen 6000 CPUs for laptops at CES 2022, featuring the company’s upgraded Zen 3 Plus architecture, a new 6nm process node, and the debut of AMD’s RDNA 2. When we saw AMD jump from 3000 to 5000 series for Zen 3 on the desktop, we were excited. AMD had three different architectures in the 3000 series – the Athlon 3000G is Zen 1, 3200G and 3400G are Zen+, and the rest of the lineup is Zen 2. However, Zen 3 core has higher IPC and are better power efficiency. These CPUs look very similar on paper, with similar clock speeds and core counts to Zen 3. The 5700U, 5500U and 5300U all use the older Zen 2 architecture, with half the 元 cache and significantly slower cores. Sadly, though it’s mostly Zen 3, AMD is filling out their mobile 5000 series with rebrands. Max boost clocks are also up, hitting up to 4.6GHz on the 5900HX and 4.8GHz on the 5980HX. 6 GHz, 52 W PL2 / Short Burst, 46 W PL1 / Sustained, Cezanne H (Zen 3). Both also have a huge (for laptops) 20MB of total cache – indicating a 16MB 元, up from 8MB last year. 6 Full HD IPS-Level 144Hz Gaming Laptop, AMD Ryzen 7 3750H 2. The AMD Ryzen 9 5900HX and Ryzen 9 5980HX are both unlocked laptop processors with 8 cores, a 45W TDP, and the ability to overclock. Meet The Unlocked AMD Laptop Chips: 5900HX and 5980HX AMD is also introducing unlocked laptop processors, with the Ryzen 5000 HX series. Surprisingly, AMD isn’t just refreshing the cores. The bulk of the new Ryzen 5000 series mobile lineup is based on Zen 3 cores, just like Ryzen 5000 on desktop. AMD is keynoting a digital CES this year, and have used the platform to announce new laptop chips. See this support document for more details macOSĭownload the macOS Installer directly from the web site. Node.js can also be installed with the IBM i Access Client Solutions product. To install Node.js 14.x from the command line, run the following as a user with *ALLOBJ special authority: yum install nodejs14 The package name is nodejs followed by the major version number (for instance, nodejs12, nodejs14 etc) LTS versions of Node.js are available from IBM, and are available via the 'yum' package manager. Node.js is available in the portage tree. Or compile it on your own using ports: cd /usr/ports/www/node & make install Install a binary package via pkg: pkg install node The most recent release of Node.js is available via the www/node port. It allows you to perform operations like install, uninstall, switch Node versions automatically based on the current directory, etc.įnm has cross-platform support (macOS, Windows, Linux) & all popular shells (Bash, Zsh, Fish, PowerShell, Windows Command Line Prompt).įnm is built with speed in mind and compatibility support for. fnmįast and simple Node.js version manager built in Rust used to manage multiple released Node.js versions. Packages compatible with Debian and Ubuntu based Linux distributions are available via Node.js snaps. Node.js binary distributions are available from NodeSource.
Some of the best teen - and pre-teen - players from the Peninsula and other parts of the state will gather at Centre Court Racquet Club this weekend for the Peninsula Tennis Patrons Association Thanksgiving Classic junior tournament. Participants with symptomatic TEPS had significantly more respiratory exacerbations than those with asymptomatic TEPS (0.23 vs 0.08 exacerbations per person-year, respectively rate ratio, 2.38, P < .001).Ĭonclusions and Relevance Participants with symptomatic TEPS did not have accelerated rates of decline in FEV 1 or increased incidence of COPD vs those with asymptomatic TEPS, but participants with symptomatic TEPS did experience significantly more respiratory exacerbations over a median follow-up of 5.8 years.E-Pilot Evening Edition Home Page Close Menu The cumulative incidence of COPD was 33.0% among participants with symptomatic TEPS vs 31.6% among those with asymptomatic TEPS (hazard ratio, 1.05 ). At a median follow-up of 5.76 years, the decline in FEV 1 was −31.3 mL/y for participants with symptomatic TEPS vs −38.8 mL/y for those with asymptomatic TEPS (between-group difference, −7.5 mL/y ). Results Of 1397 study participants, 226 had symptomatic TEPS (mean age, 60.1 years 134 were women ) and 269 had asymptomatic TEPS (mean age, 63.1 years 134 were women ). Secondary outcomes included development of COPD defined by spirometry, respiratory symptoms, rates of respiratory exacerbations, and progression of computed tomographic–defined airway wall thickening or emphysema. Main Outcomes and Measures The primary outcome was assessment for accelerated decline in lung function (FEV 1) in participants with symptomatic TEPS vs asymptomatic TEPS. Patient-reported respiratory symptoms and exacerbations were assessed every 4 months via phone calls. Participants with asymptomatic TEPS had normal spirometry and COPD Assessment Test scores of less than 10. Participants with symptomatic TEPS had normal spirometry (postbronchodilator ratio of forced expiratory volume in the first second to forced vital capacity >0.70) and COPD Assessment Test scores of 10 or greater. Respiratory symptoms were assessed with the COPD Assessment Test (range, 0 to 40 higher scores indicate more severe symptoms). Participants in SPIROMICS II had 1 additional in-person visit 5 to 7 years after enrollment in SPIROMICS I. Participants were enrolled in SPIROMICS I and II from November 10, 2010, through July 31, 2015, and followed up through July 31, 2021.Įxposures Participants in SPIROMICS I underwent spirometry, 6-minute walk distance testing, assessment of respiratory symptoms, and computed tomography of the chest at yearly visits for 3 to 4 years. Objective To define the natural history of persons with tobacco exposure and preserved spirometry (TEPS) and symptoms (symptomatic TEPS).ĭesign, Setting, and Participants SPIROMICS II was an extension of SPIROMICS I, a multicenter study of persons aged 40 to 80 years who smoked cigarettes (>20 pack-years) with or without COPD and controls without tobacco exposure or airflow obstruction. These individuals are typically excluded from chronic obstructive pulmonary disease (COPD) trials and lack evidence-based therapies. Importance People who smoked cigarettes may experience respiratory symptoms without spirometric airflow obstruction. Bradley Drummond, MD, MHS 4 MeiLan K. Han, MD, MS 16 Nadia N. Hansel, MD, MPH 19 Kinsey Helton, MS 3 Eric A. Hoffman, PhD 6,15,20 Robert J. Kaner, MD 21 Richard E. Kanner, MD 22 Jerry A. Krishnan, MD 23 Stephen C. Lazarus, MD 1,24 Fernando J. Martinez, MD, MS 21 Jill Ohar, MD 25 Victor E. Ortega, MD, PhD 26 Robert Paine III, MD 22 Stephen P. Peters, MD, PhD 25 Joseph M. Reinhardt, PhD 6 Stephen Rennard, MD 27 Benjamin M. Smith, MD, MSc 8,28 Donald P. Tashkin, MD 7 David Couper, PhD 3 Christopher B. Cooper, MD, PhD 7,29 Prescott G. Woodruff, MD, MPH 1,24 Graham Barr, MD, PhD 8,9 Eugene R. Bleecker, MD 10,11 John Boscardin, PhD 12 Russell P. Bowler, MD, PhD 13 Russell G. Buhr, MD, PhD 7 Gerard J. Criner, MD 14 Alejandro P. Comellas, MD 15 Jeffrey L. Curtis, MD 16,17 Mark Dransfield, MD 18 Claire M. Doerschuk, MD 4 Brett A. Dolezal, PhD 7 M. William McKleroy, MD 1,2 Tracie Shing, PhD 3 Wayne H. Anderson, MEd, PhD 4 et al Mehrdad Arjomandi, MD 1,5 Hira Anees Awan, MB 6 Igor Barjaktarevic, MD, PhD 7 R. Many different communities within AAPI label face their own unique challenges: from the trauma faced by those who survived wars in Laos, Cambodia, and Vietnam Japanese Americans who remember the internment camps of the WW2 era or the anxiety felt by the children of first-generation immigrants to reconcile their cultural heritage with American life. It also has a role on how we handle stress,Ĭonnect with people, and make decisions.It’s important to recognize that the term “AAPI” (Asian American / Pacific Islander) encompasses a wide range of countries, ethnicities, nationalities, and identities. Mental health in order to avoid the mental health problems that might occurĪs a result of physical illness. 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PoorPoor M e n t a l H e a l t h M e n t a l H e a l t h Good Mental HealthGood Mental Health Hypomania, paranoia, and borderline personalityhypomania, paranoia, and borderline personalityĭisorder are symptoms of poor mental health are symptoms of poor mental health. Anxiety, sadness, bipolar illness,poor mental health. Health, and human rights abuses are all related withhealth, and human rights abuses are all related with Marginalization, unhealthy lifestyle, physical ill-marginalization, unhealthy lifestyle, physical ill. Job situations, gender discrimination, socialjob situations, gender discrimination, social Rapid social change, stressfulwhat is happening on. The individual will begin to lose understanding ofthe individual will begin to lose understanding of That will make them feel helpless, and this is whenthat will make them feel helpless, and this is when They will experience mixed emotionsself-conscious. Isolate themselves from others because they areisolate themselves from others because they are People who are suffering from mental illness tend toPeople who are suffering from mental illness tend to In conclusion, having strong mental healthĪllowsallows you to care for yourself,you to care for yourself,īeing productive and stayingbeing productive and staying In conclusion, having strong mental healthalone. When an issue is too large for them to handlewhen an issue is too large for them to handleĪlone. Also, they can recognizenegative emotions. fĪctivities, overcome problems, and deal withactivities, overcome problems, and deal with your-mental-health/looking-after-your-ĭisorders begin beforedisorders begin before f the age of 14 age of 14. Mental health is carry out tasks and everydaymental health is carry out tasks and everyday A persthe ability to build positive relationships. The ability to build positive relationships. You have strong interpersonal communiication kills andcation kills and You have strong interpersonal communfunction well. It symbolizesĪ condition of well-being in which you perceive peaa condition of well-being in which you perceive peacece, feel good, and, feel good, andįunction well. Mental health, you feel good about yourself and othemental health, you feel good about yourself and otherrs. When you shows that you are aware of your emotions. Shows that you are aware of your emotions. Emotional health does not indicate that you are hapEmotional health does not indicate that you are happpy all the time. |
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